Researchers uncover how neuropeptide Y neurons mediate opioid-induced itch through disinhibition of GRP-GRPR microcircuits in spinal cord
Opioid drugs are the most commonly used analgesics for treating moderate to severe pain in clinics. While playing a major role in opioid analgesics, the μ-opioid receptor (MOR) can lead to unwanted side effects, such as respiratory inhibition, addiction, and opioid-induced constipation, due to its broad expression in the nervous system. Pruritus, or itch, is […]
2025-08-05|Research
